Rognidan And Vikruti Vigyan comprises the basic concepts of the disease and general as well as systematic methods of examination of patient. It also comprises the systemic pathology and the description of all the diseases.
The disease is the product of unwholesome interaction of man with his environment mediated through an altered sequence of events in tridosika rhythm , dosa-dhatu(dusya) combustion, biofire(agni) deficits and loss of the integrity of internal transport system of the body, the srotamsi. Disease diagnosis is must before any treatment in any system of medicine. The methods of examination, assessment criteria may vary from system to system or may depend on the physician based on his/her clinical experience. Before that, a scholar or student must know every theoretical aspects mentioned in the classics, observe the same in patients and exercise more on that to master it. So, this subject deals with etiology (hetu), pathogenesis (samprapti), symptomatology (lakshana), prognosis (sadhyasadhyatwa) and complications (updrava) of every disease as explained by Brihatrayees.